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Tapentadol is a centrally acting analgesic approved by the FDA for managing severe acute pain and chronic conditions like diabetic neuropathy. It combines two mechanisms: mu-opioid receptor agonism and norepinephrine reuptake inhibition, offering effective pain relief with a potentially improved side effect profile compared to traditional opioids.

Available in both immediate-release and extended-release formulations, Tapentadol is manufactured by Collegium Pharmaceutical, Inc. It is a Schedule II controlled substance, indicating a high potential for abuse, which may lead to severe psychological or physical dependence.

Common side effects include constipation, nausea, dizziness, and drowsiness. Serious risks involve respiratory depression, especially during initiation or dose increases, and potential interactions with other central nervous system depressants.

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